Bioprocessing engineer in cleanroom coveralls entering information for manufacturing.

Monoclonal Antibody (mAb) and Recombinant Protein Manufacturing

Innovation for streamlined and accelerated workflows.

Reimagine bioprocessing to accelerate speed to market.

Traditional bioprocessing lines can be challenging with outdated technology that can't keep up with new developments in higher-titer cell cultures and increased contaminants. We have a portfolio of solutions that can help your line run more efficiently and with excellent purity and higher yields.

Enabling high-performance single-stage clarification

A line with three curves in it and dots representing steps in a process becoming a line with two curves and dots representing steps in a process.

Save valuable time without sacrificing quality. Take a traditional processing line and condense several steps into one with 3M's portfolio for mAb and recombinant protein clarification and purification.

Streamlined handling of higher concentration cultures.
Increased efficiency through reduced unit operations.
Reduced total cost of ownership.

See the 3M difference.

Increased Yield
Decreased Cost

Compare a legacy process with two stages of depth filters in harvesting and traditional AEX and CEX columns in polishing to a process using 3M™ Harvest RC Chromatographic Clarifier and 3M™ Polisher ST. This model shows a 29% increased yield and a 16% decreased cost.

*Commercial Biosolve Process™ software package from Biopharm Services Limited was used for modeling. The results are generated for the hypothetical scenarios. Depending on product and process conditions, the effects shown here may not be realized or may not be realized to the degree shown in the scenarios. 3M data on file.

Next-generation process.

Infographic showing simplified bioprocessing by incorporating 3M™ products.

3M™ Harvest RC Chromatographic Clarifier
10x less HCP post-Protein A

High mAb product recovery (>95%)

Turbidity reduction <15 NTU

DNA reduction <500 ppb

Process intensification – process step compression
Learn more about 3M™ Harvest RC Chromatographic Clarifier
3M™ Polisher ST
HCP reduction >50% above pH 5

Virus reduction >4 logs

DNA clearance down to less than 10 ppb or reduction >4 logs or below detection

High salt and low pH tolerance

Platformability, works in a wide range of operating conditions
Learn more about 3M™ Polisher ST

Explore applications from 3M portfolio.

See how 3M solutions can be applied to your process.

View Brochure (PDF, 11.9 MB)

Industry trends: Producing mAbs at a commercial scale.

Biopharmaceutical products (biologics) are transforming the treatment of many diseases like cancer, rheumatoid arthritis (RA), Hepatitis C and Multiple Sclerosis (MS). Monoclonal antibodies (mAbs) and recombinant therapeutic proteins are the two largest biologics segments. Producing these molecules consistently at a commercial scale is both complex and costly.

Frost & Sullivan has identified key trends driving biopharmaceutical companies to adopt a sandbox approach for development of next-generation biopharmaceutical manufacturing platforms. Read more in the webinar summary.

Read the Frost & Sullivan Webinar Summary – Next-Generation Biopharmaceutical Manufacturing Platforms — US, English only (PDF, 1.19 MB)

Want to simplify your process?

Innovation in cell culture production has created additional complexities for the clarification process. 3M offers single-stage and single-use solutions to help simplify your process and increase manufacturing efficiency.

Ask an expert

Fill out this form for any technical or process-related question, and an appropriate 3M Biopharmaceutical representative will contact you to answer your question or direct your request.

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